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Opdivo outperformed standard chemotherapy with respect to two of the three most common measurements of cancer drug efficacy, overall survival and response rate. Exelixis' drug, though, was the first to outperform standard chemo on all three measurements. Continue Reading Below ADVERTISEMENT Looking ahead, Cabometyx might have a chance to expand its addressable patient population to include those diagnosed with RCC but not yet treated. Pfizer's Sutent enjoys this position now -- but might have to share it with Cabometyx before too long. In a mid-stage clinical trial, Cabometyx reduced patients' risk of disease progression or death by 31% compared with the standard therapy. The case for Novartis Unlike Exelixis, the Swiss pharma giant has dozens of products pushing and pulling at its top line. Unfortunately, sales of its former top-selling product, the blood cancer drug Gleevec, are contracting due to generic competition. As a result, the company's top line has been sliding, and so has its stock price over the past 18 months. Luckily, a handful of recent launches are positioned to help offset those losses. In particular, psoriasis treatment Cosentyx earned approval in 2015, and it finished the third quarter on an annualized run rate of $1.32 billion. The drug outperformed Johnson & Johnson's popular Stelara in a clinical trial, and could generate annual sales of around $4 billion at its peak.

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